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Low-level laser irradiation (LLLI) promotes proliferation of mesenchymal and cardiac stem cells in culture

✍ Scribed by Hana Tuby; Lidya Maltz; Uri Oron

Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
163 KB
Volume
39
Category
Article
ISSN
0196-8092

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✦ Synopsis

Abstract

Background and Objectives

Low‐level laser irradiation (LLLI) was found to promote the proliferation of various types of cells in vitro. Stem cells in general are of significance for implantation in regenerative medicine. The aim of the present study was to investigate the effect of LLLI on the proliferation of mesenchymal stem cells (MSCs) and cardiac stem cells (CSCs).

Study Design/Materials and Methods

Isolation of MSCs and CSCs was performed. The cells were cultured and laser irradiation was applied at energy densities of 1 and 3 J/cm^2^.

Results

The number of MSCs and CSCs up to 2 and 4 weeks respectively, post‐LLLI demonstrated a significant increase in the laser‐treated cultures as compared to the control.

Conclusion

The present study clearly demonstrates the ability of LLLI to promote proliferation of MSCs and CSCs in vitro. These results may have an important impact on regenerative medicine. Lasers Surg. Med. 39: 373–378, 2007. © 2007 Wiley‐Liss, Inc.

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