Low-Level expression of ETV6/TEL in patients with myelodysplastic syndrome
β Scribed by Tetsuya Yamagata; Yuka Nakamura; Kinuko Mitani
- Publisher
- Carden Jennings Publishing
- Year
- 2007
- Tongue
- English
- Weight
- 148 KB
- Volume
- 86
- Category
- Article
- ISSN
- 0925-5710
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## Abstract __ETV6/TEL__ is the first transcription factor identified that is specifically required for hematopoiesis within the bone marrow. This gene has been found to have multiple fusion partners of which 16 have been cloned. Fluorescence in situ hybridization (FISH) analysis in a patient with
We identified a novel human long fatty acyl CoA synthetase 2 gene, ACS2, as a new ETV6 fusion partner gene in a recurrent t(5;12)(q31;p13) translocation in a patient with refractory anemia with excess blasts (RAEB) with basophilia, a patient with acute myelogenous leukemia (AML) with eosinophilia, a
Apoptosis is dysregulated in patients with myelodysplastic syndrome (MDS) and acute myelogenous leukaemia (AML). FLIP (FLICE (FAS-associated death-domain-like IL-1 beta-converting enzyme)-inhibitory protein) has been described as an anti-apoptotic protein. Here, we characterize the expression level