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Low interferon binding activity of two human cell lines which respond poorly to the antiviral and antiproliferative activity of interferon

โœ Scribed by Corrado Baglioni; Andrew A. Branca; Susan B. D'Alessandro; Deborah Hossenlopp; Kailash C. Chadha


Book ID
119010553
Publisher
Elsevier Science
Year
1982
Tongue
English
Weight
413 KB
Volume
122
Category
Article
ISSN
0042-6822

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CHO cell lines that constitutively produce the murine interferon-alpha (IFN-alpha) subspecies alpha 4 and alpha 6 were constructed. The producer cell lines were protected against viral (vesicular stomatitis virus) infection by the IFN species secreted, but were resistant to the growth inhibitory act