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Low Hepatic Cytochrome P450 3A Activity is a Risk for Corticosteroid-induced Osteonecrosis

✍ Scribed by Nafziger, A N; Bertino, J S


Book ID
110019983
Publisher
Nature Publishing Group
Year
2007
Tongue
English
Weight
58 KB
Volume
82
Category
Article
ISSN
0009-9236

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Increased hepatic cytochrome P4503A acti
✍ Toshiaki Masada; Kentaro Iwakiri; Yutaka Oda; Yasunori Kaneshiro; Hiroyoshi Iwak πŸ“‚ Article πŸ“… 2008 πŸ› Elsevier Science 🌐 English βš– 171 KB

## Abstract Low hepatic cytochrome P4503A (CYP3A) activities might play an important role for inducing osteonecrosis of the femoral head (ONFH) by corticosteroids. However, the relationship between hepatic CYP3A activity and steroid‐induced ONFH is unknown. We have examined the relationship between