Low-grade lymphoma of immature T-cell phenotype in a case of lymphocytic interstitial pneumonia and Sjögren's syndrome
✍ Scribed by H.-J. SCHUURMAN; H.CH. GOOSZEN; I.W.N. TAN; P.M. KLUIN; SJ.SC. WAGENAAR; J.A.M. VAN UNNIK
- Book ID
- 108777505
- Publisher
- John Wiley and Sons
- Year
- 1987
- Tongue
- English
- Weight
- 995 KB
- Volume
- 11
- Category
- Article
- ISSN
- 0309-0167
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Sjögren's syndrome (SS) is a systemic autoimmune disorder with a strong tumor predisposition (a 44-fold elevated incidence of non-Hodgkin's lymphoma has been reported). By polymerase chain reaction analysis of t(14;18), a key lymphomagenic event in peripheral blood lymphocytes, we found a lower freq
Objective. To investigate whether a change in the CD95-related apoptosis of T lymphocytes might have a share in the development of the disease in patients with primary Sjo ¨gren's syndrome (SS). Methods. Two-color cytometric analysis was used to study the phenotype of freshly separated mononuclear