Low expression level but potent antigen presenting function of CD1d on monocyte lineage cells

Improved detection of melanoma antigen-s

Improved detection of melanoma antigen-specific T cells expressing low or high levels of CD8 by HLA-A2 tetramers presenting a Melan-A/Mart-1 peptide analogue

✍ Markus J. Maeurer; Antje Necker; Russell D. Salter; Chiara Castelli; Hanni Höhn; 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 French ⚖ 213 KB

## Abstract MHC class I tetramers containing peptide epitopes are sensitive tools for detecting antigen‐specific CD8^+^ T‐cell responses. We demonstrate here that binding of HLA‐A2 tetramers to CD8^+^ T cells specific for the melanoma‐associated antigen Melan‐A/MART‐1 can be fine‐tuned by altering