Low doses of radiation induce systemic production of cytokines: Possible contribution to leukemogenesis

✍ Scribed by Boris Tartakovsky; Orly Goldstein; Rita Krautghamer; Nechama Haran-Ghera

• Publisher: John Wiley and Sons
• Year: 1993
• Tongue: French
• Weight: 705 KB
• Volume: 55
• Category: Article
• ISSN: 0020-7136
• DOI: 10.1002/ijc.2910550217

✦ Synopsis

Abstract

Experiments were conducted to explore the possible effect of low‐dose irradiation on cytokine production in mice. SJL/J and C57BL/6J mice were exposed to 3 Gy and 4 Gy respectively. At various time intervals thereafter, lung‐conditioned media, bone‐marrow‐conditioned media and sera were collected. Interleu‐kin‐6 and macrophage‐colony‐stimulating‐factor activities were tested, lnterleukin‐6 in lung‐conditioned media from both strains was found to be significantly induced by irradiation. Macrophage‐colony‐stimulating‐factor activity was greatly enhanced in sera of irradiated SJL/J mice as well as in bone‐marrow‐conditioned media of both strains. The kinetics of the radiation‐induced interleukin 6 and macrophage‐colony‐stimulating‐factor activity differed in the 2 strains. SJL/J and C57BL/6J mice have been previously shown to be susceptible to low‐dose‐radiation‐induced leukemia. The coleukemogenic effects of both cytokines in 3 different models of experimental leukemogenesis is demonstrated.