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Low doses of methylnaloxonium in the nucleus accumbens antagonize hyperactivity induced by heroin in the rat

✍ Scribed by M. Amalric; G.F. Koob


Book ID
113220037
Publisher
Elsevier Science
Year
1985
Tongue
English
Weight
457 KB
Volume
23
Category
Article
ISSN
0091-3057

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A quaternary derivative of naloxone, methyl naloxonium chloride (MN), was administered intracerebrally to rats trained to self-administer heroin intravenously. Increases in intravenous (IV) heroin self-administration rates were found following injections of low doses of MN into the nucleus accumbens