The blood residence half-life and organ distribution of recombinant human tumor necrosis factor-alpha (TNF-alpha) encapsulated in sterically stabilized liposomes, were investigated in rats bearing a soft tissue sarcoma in the hind leg. We studied the decay in blood concentration of "empty" liposomes
✦ LIBER ✦
Low-dose tumor necrosis factor-α augments antitumor activity of stealth liposomal doxorubicin (DOXIL®) in soft tissue sarcoma-bearing rats
✍ Scribed by Timo L.M. Ten Hagen; Alexander H. Van Der Veen; Peet T.G.A. Nooijen; Sandra T. Van Tiel; Ann L.B. Seynhaeve; Alexander M.M. Eggermont
- Publisher
- John Wiley and Sons
- Year
- 2000
- Tongue
- French
- Weight
- 354 KB
- Volume
- 87
- Category
- Article
- ISSN
- 0020-7136
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## Abstract Previously we reported that encapsulation of tumor necrosis factor‐α (TNF) in pegylated (STEALTH®) liposomes (TNF‐PEGL) dramatically improved circulation times of the protein and augmented accumulation in tumor tissue. We and others have demonstrated enhanced antitumor activity of doxor