Low density lipoprotein receptor pathway in the delivery of Photofrin: How much is it relevant for selective accumulation of the photosensitizer in tumors?

New trends in photobiology: The role of

New trends in photobiology: The role of the low density lipoprotein receptor pathway in the delivery of lipophilic photosensitizers in the photodynamic therapy of tumours

✍ J.C. Mazière; P. Morlière; R. Santus 📂 Article 📅 1991 🏛 Elsevier Science 🌐 English ⚖ 817 KB

Lipoproteins are now recognized as major blood carriers of many hydrophobic porphyrins and related chromophores which are being investigated as possible photosensitizers in the photodynamic therapy of tumours. In vitro and in vivo studies have demonstrated the role of the low density lipoprotein (LD