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Low-carrier production of [15O]oxygen, water and carbon monoxide

✍ Scribed by M.S. Berridge; A.H. Terris; E.H. Cassidy

Publisher
Elsevier Science
Year
1990
Weight
229 KB
Volume
41
Category
Article
ISSN
0883-2889

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✦ Synopsis

In the course of work to label butanol with 150, it became necessary to decrease carrier oxygen levels used in ~50 production. The low carrier conditions are incompatible with widely used techniques for production of labeled water and carbon monoxide. Method modifications are reported for production of these radiopharmaceuticals under low-carrier conditions, including the use of platinum as a catalyst for [~50]water production. With these methods, it is possible to continue to produce all routine ~50 radiopharmaceuticals using a single, low-carrier, target gas.

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