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Low-avidity recognition by CD4+ T cells directed to self-antigens

✍ Scribed by John A. Gebe; Ben A. Falk; Kellee A. Rock; Sharon A. Kochik; Anne K. Heninger; Helena Reijonen; William W. Kwok; Gerald T. Nepom

Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
371 KB
Volume
33
Category
Article
ISSN
0014-2980

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Recognition of rheumatoid arthritis syno
Recognition of rheumatoid arthritis synovial antigen by CD4+,CD8− T cell clones established from rheumatoid arthritis joints
✍ Tomoko Toyosaki; Yuji Tsuruta; Takeshi Yoshioka; Hiroshi Takemoto; Ryuji Suzuki; 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 865 KB

Objective. To investigate the rheumatoid arthritis (RA)-specific autoantigen(s) recognized by CD4+ T cells in patients with RA. Methods. CD4+,CD45RO+ T cell clones were established from the joints of RA patients, and were examined for their proliferative response to synovial cells. Results. Eight of