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Low affinity nerve growth factor receptor binding in normal and Alzheimer's disease basal forebrain

✍ Scribed by Treanor, J.J.S.; Dawbarn, D.; Allen, S.J.; MacGowan, S.H.; Wilcock, G.K.


Book ID
122348417
Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
373 KB
Volume
121
Category
Article
ISSN
0304-3940

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Mutant PC12 cell clones (PC84 cells) were obtained by transfection with nerve growth factor (NGF) cDNA. These cells secreted active NGF, extended short processes, and proliferated faster than the parental PC12 cells. These features are of great interest because the parental PC12 cells cease prolifer