Endothelial cells, as they normally exist in the vasculature as quiescent cells, perform several functions. In an inflammatory response, endothelial cells are activated to up-regulate a number of genes, including E-selectin (ELAM-l), VCAM-1, ICAM-1, interleukin (IL)-l, IL-8 and plasminogen activator
✦ LIBER ✦
Lovastatin-stimulated superinduction of E-selectin, ICAM-1 and VCAM-1 in TNF-α activated human vascular endothelial cells
✍ Scribed by Annette Schmidt; Christian Goepfert; Kirsten Feitsma; Eckhart Buddecke
- Book ID
- 119435601
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- English
- Weight
- 303 KB
- Volume
- 164
- Category
- Article
- ISSN
- 0021-9150
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## Abstract Attachment to, and migration of leukocytes into the vessel wall is an early event in atherogenesis. Expression of cell adhesion molecules by the arterial endothelium may play a major role in atherosclerosis. It has been suggested that antioxidants inhibit the expression of adhesion mole