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Lovastatin and gemfibrozil in the treatment of type 2a and type 2b hyperlipoproteinemia

✍ Scribed by M. J. Tikkanen; J. -P. Ojala; E. Helve

Publisher
Springer
Year
1991
Tongue
English
Weight
334 KB
Volume
40
Category
Article
ISSN
0031-6970

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Type III hyperlipoproteinemia (HLP) is usually associated with homozygosity for apolipoprotein (apo) E2 (Arg112 --> Cys, Arg158 --> Cys). This common apo E isoform is defective in its binding to lipoprotein receptors. However, other rare mutations in the apo epsilon gene may also, in part dominantly