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Loss ofO6-Methylguanine-DNA Methyltransferase Protein Expression Is a Favorable Prognostic Marker in Diffuse Large B-Cell Lymphoma

✍ Scribed by Toshihito Ohno; Junji Hiraga; Haruhiko Ohashi; Chiho Sugisaki; Eika Li; Haruhiko Asano; Tastuya Ito; Hirokazu Nagai; Yoriko Yamashita; Naoyoshi Mori; Tomohiro Kinoshita; Tomoki Naoe


Book ID
111835536
Publisher
Carden Jennings Publishing
Year
2006
Tongue
English
Weight
855 KB
Volume
83
Category
Article
ISSN
0925-5710

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Loss of expression of ZAC/PLAGL1 in diff
✍ Elizabeth M. A. Valleley; Sarah F. Cordery; Ian M. Carr; Kenneth A. MacLennan; D πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons 🌐 English βš– 278 KB

## Abstract __ZAC/PLAGL1__ is a ubiquitously expressed, imprinted tumor suppressor gene located on 6q24, a chromosomal region that is frequently deleted in diffuse large B‐cell lymphoma (DLBCL). Like p53, ZAC regulates cell cycle arrest and apoptosis concomitantly, and loss of expression is implica