Breakthrough after varicella vaccination occurs in approximately 2.6%โผ18.6% of immunocompetent children, but the reason has not been demonstrated clearly. As a first defense, specific secretory IgA antibody on the mucosa plays an important role in preventing invasion of microorganisms. To examine in
โฆ LIBER โฆ
Loss of Varicella Zoster Virus Antibodies Despite Detectable Cell Mediated Immunity after Vaccination
โ Scribed by B. Ludwig; F. B. Kraus; R. Allwinn; S. Keim; H. W. Doerr; S. Buxbaum
- Book ID
- 107705451
- Publisher
- Springer-Verlag
- Year
- 2006
- Tongue
- English
- Weight
- 316 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0300-8126
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An interferon-gamma ELISPOT assay has been developed for assessment of cellular immune responses to Varicella-Zoster Virus (VZV) in large, multi-center clinical vaccine trials. We show that the assay performed best when testing peripheral blood mononuclear cells (PBMCs) that had been isolated and th