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Loss of translational entropy in binding, folding, and catalysis

✍ Scribed by L. Mario Amzel

Book ID
101228757
Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
50 KB
Volume
28
Category
Article
ISSN
0887-3585

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✦ Synopsis

There is a loss of translational entropy associated with the formation of a complex between two molecules in solution. Estimation of this contribution is essential for understanding binding, protein-protein association, and catalysis. Based on the cell model of liquids, it is possible to estimate the loss of translational entropy in all these cases. The resulting formulas are straightforward, and the calculations are easy to perform. Comparison of the results with experimental data suggests that the proposed method provides estimates that are much more accurate than those obtained with existing methods.

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