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Loss of the TEL/ETV6 gene by a second translocation in ALL patients with t(12;21)

✍ Scribed by Maryvonne Busson-Le Coniat; Hélène Poirel; Thierry Leblanc; Olivier A Bernard; Roland Berger

Book ID: 114119657
Publisher: Elsevier Science
Year: 1999
Tongue: English
Weight: 202 KB
Volume: 23
Category: Article
ISSN: 0145-2126
DOI: 10.1016/s0145-2126(99)00105-8

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ETV6 (TEL) is rearranged in various types of hematologic malignancies. The B-cell precursor acute lymphoblastic leukemia (ALL) cell line SUP-B2 has a t(6;12)(q23;p13) involving ETV6 at 12p13 and a submicroscopic deletion of the other ETV6 allele. The reciprocal translocation results in the fusion of