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Loss of T-cell IL-6R expression during inflammation: IL-6 trans-signaling regulates T-cell trafficking and effector characteristics

✍ Scribed by Gareth W. Jones; Rachel M. McLoughlin; Victoria J. Hammond; Clare R. Parker; John D. Williams; Raj Malhotra; Jürgen Scheller; Stefan Rose-John; Nicholas Topley; Simon A. Jones

Book ID
116399298
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
63 KB
Volume
48
Category
Article
ISSN
1043-4666

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## Abstract Human T‐cell leukemia virus type‐I (HTLV‐I) encodes for the viral protein Tax, which is known to significantly disrupt transcriptional control of cytokines, cytokine receptors and other immuno‐modulatory proteins in T cells. Specific dysregulation of these factors can alter the course a