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Loss of standard type of CD44 expression in invaded area as a good indicator of lymph-node metastasis in colorectal carcinoma

✍ Scribed by Takayuki Asao; Jun-ichi Nakamura; Yoshinori Shitara; Souichi Tsutsumi; Erito Mochiki; Tatsuo Shimura; Sei-ichi Takenoshita; Hiroyuki Kuwano


Book ID
105507092
Publisher
Springer
Year
2000
Tongue
English
Weight
623 KB
Volume
43
Category
Article
ISSN
0012-3706

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Loss of Smad4 protein expression and 18q
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## Abstract ## Purpose Chromosome 18q21 deletion and Smad4 protein inactivation have been reported as molecular markers predicting unfavorable outcome in colorectal cancers and, in a previous report, we recently revealed that these molecules are closely associated with distant metastasis, which is