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Loss of runt-related transcription factor 3 causes development and progression of hepatocellular carcinoma

✍ Scribed by Hidenori Shiraha; Shin-ichi Nishina; Kazuhide Yamamoto

Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
139 KB
Volume
112
Category
Article
ISSN
0730-2312

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✦ Synopsis

Abstract

Runt‐related transcription factor 3 (RUNX3) is reported as a tumor suppressor gene for gastric cancer, and may be important in the development of hepatocellular carcinoma (HCC). RUNX3 expression is frequently lost or decreased by hemizygous deletion or hypermethylation of its promoter lesion in HCC. The significance of decreased expression of RUNX3 in HCC has not been fully elucidated, but is likely related to dysfunction of cell cycle regulation, decrement of apoptosis, enhancement of angiogenesis, and development of epithelial–mesenchymal transition. RUNX3 is a promising candidate as a tumor suppressor gene for HCC. J. Cell. Biochem. 112: 745–749, 2011. © 2010 Wiley‐Liss, Inc.

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