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Loss of reactivity of a BALB/c myeloma tumor with allogeneic and syngeneic cytotoxic T lymphocytes

✍ Scribed by J. H. Russel; A. H. Hale; D. Inbar; H. N. Eisen

Publisher
John Wiley and Sons
Year
1978
Tongue
English
Weight
674 KB
Volume
8
Category
Article
ISSN
0014-2980

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✦ Synopsis

Abstract

It was previously observed that MOPC‐315EL, a subline of the BALB/c myeloma tumor MOPC‐315, varies in its ability to interact with primary anti‐H‐2^d^ cytotoxic thymus‐derived lymphocytes (CTL) while remaining invariant in its expression of cell surface antigens recognized by anti‐H‐2^d^ sera. This paper demonstrates (a) that secondary anti‐H‐2^d^ CTL also fail to recognize the late tumor cells, and (b) that two other CTL systems (anti‐minor histocompatibility antigens and anti‐2,4,6‐trinitrophenyl), which require recognition of both H‐2 products and other surface antigens, also fail to react with the late tumor cells. The defect in the late tumor cells was evident when they were used as targets, inhibitors, and stimulators of CTL activity.

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