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Loss of promoter methylation contributes to the expression of functionally impaired PRDM1β isoform in diffuse large B-cell lymphoma

✍ Scribed by Yi-Wen Zhang; Hong-Qiang Xie; Yu Chen; Bo Jiao; Zhi-Xiang Shen; Sai-Juan Chen; Wei-Li Zhao


Book ID
107619138
Publisher
Carden Jennings Publishing
Year
2010
Tongue
English
Weight
369 KB
Volume
92
Category
Article
ISSN
0925-5710

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Loss of expression of ZAC/PLAGL1 in diff
✍ Elizabeth M. A. Valleley; Sarah F. Cordery; Ian M. Carr; Kenneth A. MacLennan; D 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 278 KB

## Abstract __ZAC/PLAGL1__ is a ubiquitously expressed, imprinted tumor suppressor gene located on 6q24, a chromosomal region that is frequently deleted in diffuse large B‐cell lymphoma (DLBCL). Like p53, ZAC regulates cell cycle arrest and apoptosis concomitantly, and loss of expression is implica