## Abstract 1,25βDihydroxyvitamin D~3~ (1,25(OH)~2~D~3~) treatment of osteoblastic cells was shown previously to attenuate Parathyroid hormone (PTH) response by inhibiting adenylyl cyclase (AC) activity. In this study, we have investigated the mechanism by which 1,25(OH)~2~D~3~ inhibits AC in rat o
β¦ LIBER β¦
Loss of parathyroid hormone-stimulated 1,25-dihydroxyvitamin D3 production in aging does not involve protein kinase A or C pathways
β Scribed by Jason Friedlander; Mark Janulis; Vrishali Tembe; Heung Kyu Ro; Man-Sau Wong; Dr. Murray J. Favus
- Book ID
- 112119230
- Publisher
- American Society for Bone and Mineral Research
- Year
- 2009
- Tongue
- English
- Weight
- 618 KB
- Volume
- 9
- Category
- Article
- ISSN
- 0884-0431
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The cytokine interleukin-6 (IL-6) was produced by neonatal mouse parietal bones during a 6- or 48-hour culture period in response to prostaglandin E2 (PGE2) and bovine parathyroid hormone (PTH) 1-34 fragment but not 1,25-dihydroxyvitamin D3 [1,25(OH)2D3]. At the same time there was an increase in ta