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Loss of maspin expression contributes to a more invasive potential in malignant melanoma

✍ Scribed by Denk, Alexandra E. ;Bettstetter, Marcus ;Wild, Peter J. ;Hoek, Keith ;Bataille, Frauke ;Dietmaier, Wolfgang ;Bosserhoff, Anja K.


Book ID
111260047
Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
679 KB
Volume
20
Category
Article
ISSN
0893-5785

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The G 1 /S checkpoint of the cell cycle is regulated by p16, p53 and RB tumor suppressor genes. Loss of expression of the p16 INK4 tumor suppressor protein, the product of the CDKN2 gene, has been associated with a wide variety of human malignancies. Mutations, loss of heterozygosity and deletions o