Loss of let-7 binding sites resulting from truncations of the 3′ untranslated region of HMGA2 mRNA in uterine leiomyomas

Identification of novel HMGA2 fusion seq

Identification of novel HMGA2 fusion sequences in lipoma: Evidence that deletion of let-7 miRNA consensus binding site 1 in the HMGA2 3′ UTR is not critical for HMGA2 transcriptional upregulation

✍ Xiaoke Wang; Rachael L. Hulshizer; Michele R. Erickson-Johnson; Heather C. Flynn 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 271 KB

## Abstract Lipoma is a benign tumor composed of mature adipocytes and one of the most common mesenchymal tumors seen in adults. Rearrangement of __HMGA2__ in chromosome band 12q15 has been found in ∼60–70% of ordinary lipomas with cytogenetic abnormalities. Herein, we report two novel __HMGA2__ fu