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Loss of imprinting ofIGF2andH19,loss of heterozygosity ofIGF2RandCTCF,andHelicobacter pyloriinfection in laryngeal squamous cell carcinoma

✍ Scribed by Ivana Grbesa; Marino Marinkovic; Mirko Ivkic; Bozo Kruslin; Renata Novak-Kujundzic; Boris Pegan; Ozren Bogdanovic; Vladimir Bedekovic; Koraljka Gall-Troselj


Publisher
Springer
Year
2008
Tongue
English
Weight
250 KB
Volume
86
Category
Article
ISSN
0946-2716

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## Abstract ## Background __IGF2__ and __H19__ are reciprocal imprinted genes with paternal and maternal monoallelic expression, respectively. This is interesting, because __IGF2__ is known as a growth factor, and __H19__ encodes a RNA with putative tumor suppressor action. Furthermore, __IGF2__ a

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## Abstract ## Background. Microsatellite instability (MSI) in head and neck squamous cell carcinoma (HNSCC) has been reported with a wide range of frequencies. The aim of our study was to disclose the frequency and basis of MSI in HNSCC and to correlate MSI and findings on loss of heterozygosity

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## Abstract Loss of heterozygosity (LOH) in chromosomal regions that harbor tumor suppressor genes from tumor tissue may lead to decreased survival time in cancer patients with squamous cell carcinoma of the head and neck (HNSCC). We studied 8 regions frequently lost in HNSCC in 150 patients having

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## Abstract The __p16__^INK4a^ gene, localized within chromosome 9p21, has been identified as a cyclin‐dependent kinase inhibitor and may negatively regulate the cell cycle acting as a tumor suppressor. Genetic alterations involving the 9p21 region are common in human cancers. A consecutive series