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Loss of IL-7Ra is Associated With CD4+ T Cell Depletion, High IL-7 Levels and CD28 Down-regulation in HIV Infected Patients

✍ Scribed by Bence Rethi, Caroline Fluur, Ann Atlas, Sven Grützmeier, Angelo De Milito…


Book ID
120692777
Publisher
BioMed Central
Year
2005
Tongue
English
Weight
78 KB
Volume
2
Category
Article
ISSN
1742-4690

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The expression of interleukin 7 receptor alpha high (IL-7R␣ high ) discriminates between activated CD25 ϩ CD45RO ϩ CD4 ϩ T cells [IL-7R␣ high and forkhead box P3-negative (FoxP3 Ϫ )] and regulatory T cells (IL-7R␣ low and FoxP3 ϩ ). The IL-7R␣ high CD25 ϩ CD45RO ϩ CD4 ϩ FoxP3 Ϫ T cell population has