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Loss of heterozygosity of theMEN1gene in a large series of TSH-secreting pituitary adenomas

✍ Scribed by Asteria, C.; Anagni, M.; Persani, L.; Beck-Peccoz, Paolo

Book ID
125334852
Publisher
Springer-Verlag
Year
2001
Tongue
English
Weight
145 KB
Volume
24
Category
Article
ISSN
0391-4097

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The MEN1 gene on chromosome 11q13 is mutated in patients afflicted with multiple endocrine neoplasia syndrome type 1 (MEN1). These patients develop endocrine tumours of the pancreas, the parathyroid, and the anterior pituitary. In order to determine the role of MEN1 in sporadic pituitary adenomas, 6