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Loss of heterozygosity of the VHL gene identifies malignancy and predicts death in follicular thyroid tumors

โœ Scribed by Jennifer L. Hunt; John H. Yim; Michael Tometsko; Sydney D. Finkelstein; Patricia Swalsky; Sally E. Carty


Book ID
119374216
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
82 KB
Volume
134
Category
Article
ISSN
0039-6060

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The PTEN (MMAC1/TEP1) tumor suppressor gene was recently isolated and mapped to human chromosome band 10q23. Homozygous deletions and mutations of PTEN were observed in cell lines and sporadic cancers of the breast, kidney, and central nervous system. Germline mutations in PTEN were recently found i