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Loss of heterozygosity in tuberous sclerosis hamartomas.

✍ Scribed by Sepp, T; Yates, J R; Green, A J


Book ID
125810705
Publisher
BMJ Publishing Group
Year
1996
Tongue
English
Weight
389 KB
Volume
33
Category
Article
ISSN
0022-2593

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To investigate the molecular mechanisms of tuberous sclerosis (TSC) histopathologic lesions, we have tested for loss of heterozygosity the two TSC loci (TSCI and TSC2) and seven tumor suppressor gene-containing regions (TP53, NFI, NF2, BRCA I, APC, VHL, and MLM) in 20 hamartomas from 18 TSC patients

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