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Loss of heterozygosity in malignant melanoma at loci on chromosomes 11 and 17 implicated in the pathogenesis of other cancers

✍ Scribed by I. P. M. Tomlinson; A. J. Gammack; J. E. Stickland; G. J. Mann; R. M. Mackie; R. F. Kefford; J. O'D. McGee

Publisher: John Wiley and Sons
Year: 1993
Tongue: English
Weight: 351 KB
Volume: 7
Category: Article
ISSN: 1045-2257
DOI: 10.1002/gcc.2870070310

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✦ Synopsis

Forty

-six cases of sporadic melanoma have been investigated for loss of heterozygosity at 4 loci: D I IS29 ( I lq23), YNZ22 (I 7p I 3.3), 7P53 (I 7p I 3. I ); and NM23 ( 17q22). Each of the loci is thought to be important in the pathogenesis of other turnours. Mutations were found infrequently at the YNZ22, NM23, and 7/33 loci. At D I I S29, however, the frequency of mutation in the melanoma samples was high (67%) and mutations at this locus were associated with younger age at presentation. This region of chromosome I I is also commonly mutated in breast cancers and haematological malignancies. Genetic aberrations at D I I S29 may therefore represent nonspecific mutations found in several malignancies or part of a pathway common to the malignant phenotype. Genes Chrom Cancer 7: I69-I 72 ( I 993). 0 I993 Wiley-Liss, Inc.

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