Primary breast tumors were tested for loss of heterozygosity (LOH), on chromosome 9p with microsatellite markers restricted to a 28 cM region including the MTSl gene. LOH was found with at least I marker in 38% of the 20 I cases analyzed. A high frequency of deletions was detected at the 9p23-pZI re
Loss of heterozygosity at pseudoautosomal regions in human breast cancer and association with negative hormonal phenotype
β Scribed by Laura Roncuzzi; Irene Brognara; Stefania Cocchi; Wainer Zoli; Anna Gasperi-Campani
- Book ID
- 114135307
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- English
- Weight
- 176 KB
- Volume
- 135
- Category
- Article
- ISSN
- 0165-4608
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
TP53 abnormalities have been reported as an early event in the process of cellular transformation of human breast cancers, and involved in mammary-tumor evolution, from in situ to invasive disease. In this study, node-negative (N-) tumors were examined for TP53 allelic loss in relation to different
## Abstract Sixty DNA samples from breast carcinoma (BC) patients were analyzed by Southern blot to examine certain oncogene and antiβoncogene alterations. Amplification of the HERβ2 oncogene was detected in 15 tumours (25%), cβmyc in 2 (3%) only and HERβ1 in none. Distribution of Hrasβ1 oncogene a
## Abstract The __BRCA1__ and __BRCA2__ genes are responsible for a high proportion of familial breast cancer; germline mutations in these genes confer a lifetime risk of about 70% for developing breast cancer. Most of the described deleterious mutations are small deletions or insertions that origi