Eleven patients with chronic hepatitis D virus (HDV) infection who had chronic active hepatitis and HDV antigen on liver biopsy were randomised in a crossover therapeutic trial of interferon-alpha 2b vs. no therapy. Nine patients had a history of intravenous drug use (drug free > 6 months before the
LOSS OF HBsAg WITH INTERFERON THERAPY IN CHRONIC HEPATITIS B VIRUS INFECTION
โ Scribed by Alexander, GraemeJ.M.; Fagan, ElizabethA.; Daniels, HelenaM.; Brahm, Javier; Smith, HeatherM.; Eddleston, AdrianL.W.F.; Williams, Koger
- Book ID
- 122833794
- Publisher
- The Lancet
- Year
- 1987
- Tongue
- English
- Weight
- 694 KB
- Volume
- 330
- Category
- Article
- ISSN
- 0140-6736
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Spontaneous loss of HBsAg is infrequent in adult HBV carriers. Little is known about this serological change in children. In a prospective study of 420 hepatitis B virus-carrier children who were observed for 1 to 12 yr (mean = 4.3 yr), spontaneous loss of HBsAg occurred in 10 patients, with an aver
Reinfection with hepatitis B virus after orthotopic liver transplantation is nearly universal in patients who have not received posttransplant immunoprophylaxis. Recurrence almost invariably leads to chronic liver disease. Interferon has been used both prophylactically and therapeutically but has no