Loss of expression of chromosome 16q genes DPEP1 and CTCF in lobular carcinoma in situ of the breast
โ Scribed by Andrew R. Green; Sophie Krivinskas; Peter Young; Emad A. Rakha; E. Claire Paish; Desmond G. Powe; Ian O. Ellis
- Book ID
- 106378081
- Publisher
- Springer US
- Year
- 2008
- Tongue
- English
- Weight
- 378 KB
- Volume
- 113
- Category
- Article
- ISSN
- 0167-6806
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Lobular carcinoma in situ (LCIS) of the breast is commonly identified as an incidental finding in breast biopsies performed because of either a mammographic abnormality or a palpable mass. Although long recognized as an entity, the significance and optimal treatment of LCIS remains controversial. In
## Abstract Chromosome arm 16q is a common site of loss of heterozygosity (LOH) in Wilms tumors (WTs). The mechanism and consequences of 16q LOH are not known, but the __CTCF__ gene, in band 16q22, is a candidate target gene. CTCF protein binds to DNA upstream of the __H19__ gene on chromosome band