𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Loss of der(3) in renal carcinoma cells of a patient with constitutional t(3;12)

✍ Scribed by Gyula Kovacs; Eberhard Hoene

Publisher
Springer
Year
1988
Tongue
English
Weight
615 KB
Volume
78
Category
Article
ISSN
0340-6717

No coin nor oath required. For personal study only.

✦ Synopsis

Cytogenetic studies were performed on peripheral lymphocytes, normal kidney cells, and tumor cells of a patient with renal cell carcinoma. Chromosome analysis of normal somatic cells revealed a constitutional t(3;12)(q13.2;q24.1) and a genomic instability involving the derivative chromosome 12. On the other hand, tumor cells were characterized by loss of der(3), supporting the hypothesis that loss of a specific 3p segment is associated with the development of renal cancer.

πŸ“œ SIMILAR VOLUMES

Defining the position of the breakpoint
Defining the position of the breakpoint of the constitutional t(3;6) occurring in a family with renal cell carcinoma
✍ Anke van den Berg; Anneke Y. van der Veen; Miriam M. F. Hulsbeek; Gyula Kovacs; πŸ“‚ Article πŸ“… 1995 πŸ› John Wiley and Sons 🌐 English βš– 463 KB

In a family with a constitutional translocation t(3;6), the oldest member carrying the translocation had developed multiple nonpapillary renal cell carcinomas (RCCs). The translocation breakpoint was positioned between 3p I 3 and 3p 14. I. This is close t o the region in which a t(3;8) breakpoint ha

Characterization of a 3;6 translocation
Characterization of a 3;6 translocation associated with renal cell carcinoma
✍ Rebecca E. Foster; Mahera Abdulrahman; Mark R. Morris; Elena Prigmore; Susan Gri πŸ“‚ Article πŸ“… 2007 πŸ› John Wiley and Sons 🌐 English βš– 639 KB

## Abstract The most frequent cause of familial clear cell renal cell carcinoma (RCC) is von Hippel–Lindau disease and the __VHL__ tumor suppressor gene (TSG) is inactivated in most sporadic clear cell RCC. Although there is relatively little information on the mechanisms of tumorigenesis of clear

Characterization of t(6;11)(p21;q12) in
Characterization of t(6;11)(p21;q12) in a renal-cell carcinoma of an adult patient
✍ Lorenza Pecciarini; M. Giulia Cangi; Crocifissa Lo Cunsolo; Ettore Macri'; Elena πŸ“‚ Article πŸ“… 2007 πŸ› John Wiley and Sons 🌐 English βš– 514 KB

## Abstract Renal‐cell carcinoma (RCC) constitutes a heterogeneous group of tumors with specific chromosome aberrations. Recently, a new small group of RCC, occurring in children and young adults, has been described as characterized by t(6;11)(p21;q12). It has been shown that this translocation res