Loss of cytokeratin 14 expression is related to human papillomavirus type and lesion grade in squamous intraepithelial lesions of the cervix
β Scribed by Shirley A Southern; Ian W McDicken; C.Simon Herrington
- Book ID
- 117818533
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- English
- Weight
- 319 KB
- Volume
- 32
- Category
- Article
- ISSN
- 1532-8392
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## Abstract The association between total and integrated HPVβ33 DNA loads and highβgrade squamous intraepithelial lesions (HSIL) of the uterine cervix was investigated. Of 5,347 women recruited in 4 studies, 89 (64 without SIL, 7 lowβgrade SIL (LSIL), 15 HSIL, 3 unknown grade) were infected by HPVβ
A polymorphism at codon 72 of the p53 gene, resulting in either an arginine or a proline residue in the protein, has been reported to affect the susceptibility of p53 to human papillomavirus (HPV) E6-mediated degradation in cultured cells. However, the relevance of this polymorphism to naturally occ