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Loss of Chromosome 17 loci in prostate cancer detected by polymerase chain reaction quantitation of allelic markers

✍ Scribed by Arthur R. Brothman; Michael R. Steele; Briana J. Williams; Emma Jones; Shannon Odelberg; Hans M. Albertsen; Lynn B. Jorde; L. Ralph Rohr; Robert A. Stephenson

Publisher: John Wiley and Sons
Year: 1995
Tongue: English
Weight: 619 KB
Volume: 13
Category: Article
ISSN: 1045-2257
DOI: 10.1002/gcc.2870130408

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✦ Synopsis

Using a polymerase chain reaction/microsatellite marker system, we demonstrated that 6 of 22 (27%) clinical stage B (early) primary prostate tumors showed loss of heterozygosity at one or more of five loci on chromosome 17. The sensitivity of this study was increased by use of a Phosphorlmager and statistical analysis of replicate tumor-normal DNA pairs. Two patients showed tumor-specific interstitial loss at a locus in close proximity to the familial breast cancer gene BRCAI. These findings suggest that genes on the proximal long arm of chromosome I7 play a pivotal role in the early development of at least a subset of prostatic tumors. Genes Chromosom Cancer 13:278-284 (1995). 0 1995 Wiley-Liss. Inc.

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