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Loss of BBS proteins causes anosmia in humans and defects in olfactory cilia structure and function in the mouse

✍ Scribed by Kulaga, Heather M; Leitch, Carmen C; Eichers, Erica R; Badano, Jose L; Lesemann, Alysa; Hoskins, Bethan E; Lupski, James R; Beales, Philip L; Reed, Randall R; Katsanis, Nicholas


Book ID
109919038
Publisher
Nature Publishing Group
Year
2004
Tongue
English
Weight
567 KB
Volume
36
Category
Article
ISSN
1061-4036

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## Abstract Accumulating evidence has indicated that gain‐of‐function in β‐amyloid production may be not the necessary mechanism for mutant presenilin‐1 (PS1) or PS2 to cause familial Alzheimer's disease (AD). In the present article, we show that conditional knockout of PS1 from the adult stage in