Loss of presenilin function causes Alzhe
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Qian Chen; Akira Nakajima; Se Hoon Choi; Xiaoli Xiong; Ya-Ping Tang
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Article
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2008
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John Wiley and Sons
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English
β 448 KB
## Abstract Accumulating evidence has indicated that gainβofβfunction in Ξ²βamyloid production may be not the necessary mechanism for mutant presenilinβ1 (PS1) or PS2 to cause familial Alzheimer's disease (AD). In the present article, we show that conditional knockout of PS1 from the adult stage in