## Abstract Methylation of lysine 27 on histone H3 (H3K27) by the EZH2 complex is an epigenetic mark that mediates gene silencing. EZH2 is overexpressed in many cancers and correlates with poor prognosis in both breast and prostate cancers. However, the status of H3K27 methylation and its clinical
Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer
β Scribed by Fraga, Mario F; Ballestar, Esteban; Villar-Garea, Ana; Boix-Chornet, Manuel; Espada, Jesus; Schotta, Gunnar; Bonaldi, Tiziana; Haydon, Claire; Ropero, Santiago; Petrie, Kevin
- Book ID
- 109919132
- Publisher
- Nature Publishing Group
- Year
- 2005
- Tongue
- English
- Weight
- 768 KB
- Volume
- 37
- Category
- Article
- ISSN
- 1061-4036
- DOI
- 10.1038/ng1531
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Communicated by Albert de la Chapelle Allelic deletions, which are suggestive for the presence of tumor suppressor genes, represent a common event in endometrial cancer (EC). Previous loss-of-heterozygosity studies for human chromosome 10q identified a candidate deletion interval at 10q25-q26, w
## Abstract Loss of heterozygosity (LOH) at chromosome 13q14 is one of the most recurrent anomalies observed in sporadic prostate tumors. This LOH is believed to unmask recessive mutations that inactivate a tumorβsuppressor gene(s) which otherwise regulates normal cell growth and suppresses abnorma