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Loss of 1p and 7p in radiation-induced meningiomas identified by comparative genomic hybridization

✍ Scribed by Evica Rajcan-Separovic; John Maguire; Tatiana Loukianova; Meimun Nisha; Dagmar Kalousek

Book ID
114135563
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
114 KB
Volume
144
Category
Article
ISSN
0165-4608

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Meningioma is a common tumor of the meninges covering the central nervous system. Although generally a benign tumor, meningioma often recurs and is malignant in 5-10% of all cases. Loss of chromosome 22 loci, and specifically inactivation of the NF2 tumor suppressor gene, is considered one of severa