## Abstract Recent studies have shown the involvement of the Fas system (Fas receptor and its ligand FasL) in cancerous processes. The absence or downregulation of Fas, reported in the majority of human tumors, conflicts with its presence in cancerous cells from the same tumors but maintained __in
Loss- and Gain-of-Function Mutations in Cancer: Mass-action, Spatial and Hierarchical Models
β Scribed by Natalia L. Komarova
- Book ID
- 106431069
- Publisher
- Springer
- Year
- 2006
- Tongue
- English
- Weight
- 463 KB
- Volume
- 128
- Category
- Article
- ISSN
- 0022-4715
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
As more studies are turning to bioinformatic prediction programs to assess the potential impact of amino acid substitutions, it is relevant to evaluate the prediction results these programs give in genes that have been well-characterized for Mendelian diseases. Eight genes responsible for neurodegen
## Abstract Germline mutations in DNA mismatch repair genes underlie one of the most common hereditary cancer predisposition syndromes known in humans, hereditary nonpolyposis colorectal cancer (HNPCC). Defects of the DNA mismatch repair system are also prevalent in sporadic colorectal cancers. The
## Abstract Myosin XVA is an unconventional myosin which has been implicated in autosomal recessive nonsyndromic hearing impairment (ARNSHI) in humans. In __Myo15__A mouse models, vestibular dysfunction accompanies the autosomal recessive hearing loss. Genomewide homozygosity mapping and subsequent