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Losartan decreases vasopressin-mediated cAMP accumulation in the thick ascending limb of the loop of Henle in rats with congestive heart failure

✍ Scribed by M. Torp; L. Brønd; N. Hadrup; J. B. Nielsen; J. Prætorius; S. Nielsen; S. Christensen; T. E. N. Jonassen


Book ID
111383627
Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
772 KB
Volume
190
Category
Article
ISSN
1748-1708

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✍ A. Stefano; M. Wittner; B. Corman 📂 Article 📅 1991 🏛 Springer 🌐 English ⚖ 880 KB

The maximal urinary osmolality that can be reached by the kidney is reduced with age. This may be due to impaired NaC1 transport by the medullary thick ascending limb of Henle's loop, which is part of the renal concentrating mechanism and is modulated by antidiuretic hormone (ADH). We therefore test