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Longitudinal study of serum neutralization of HIV-1 in infected plasma donors

✍ Scribed by Arthur V. Abelian; Shreesh Saurya; Stephen Ash; Abraham Karpas

Publisher
John Wiley and Sons
Year
2001
Tongue
English
Weight
201 KB
Volume
65
Category
Article
ISSN
0146-6615

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Earlier studies provided suggestive evidence about the effectiveness of passive immunotherapy for AIDS patients using plasma donated by healthy HIV‐1 infected individuals and revealed beneficial effects of plasmapheresis for the immune system of the donors. In this study, anti‐HIV‐1 neutralizing activity in 31 healthy HIV‐1 infected donors of plasma participating in a passive immunotherapy study was investigated as a function of time. Average studied period was 33 months. Using the highly cytopathic HIV‐1 NDK strain and MOLT4 cells, it was shown by means of syncytia formation inhibition assay and polyclonal HIV‐1 antigen‐capture assay that viral neutralizing titers tend either to remain unchanged or increase over time. These findings support the notion that the immune system is not affected adversely in HIV‐1 infected plasma donors and lend further support to the feasibility of passive immunotherapy for AIDS patients. J. Med. Virol. 65:649–658, 2001. Β© 2001 Wiley‐Liss, Inc.

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