Longitudinal studies on the development of diabetes in individualMacaca nigra

✍ Scribed by Charles F. Howard

• Book ID: 104779237
• Publisher: Springer
• Year: 1986
• Tongue: English
• Weight: 657 KB
• Volume: 29
• Category: Article
• ISSN: 0012-186X
• DOI: 10.1007/bf00452067

✦ Synopsis

Development of spontaneous diabetes has been monitored in individual Macaca nigra. In this study, pancreatic biopsies were taken, islets were assessed morphologically, and results were related to the metabolic/clinical status. A biopsy or autopsy sample was obtained 4 to 10 years later, and the islet morphological state was again related to the metabolic/clinical status. Metabolic deterioration was correlated to the islet lesion, in which there was gradual loss of islet secretory cells and concurrent amyloid deposition. As nondiabetic monkeys with 0 to 3% islet amyloid progressed up to 20 to 40% amyloid, the insulin secretion and glucose clearance were both decreased (p< 0.01), and the glucose and glucagon levels increased (p= 0.05). Impaired monkeys progressed to overt diabetes when islet amyloid exceeded 50 to 60%. Diabetic monkeys developed hyperglycaemia, along with impaired insulin secretion and glucose clearance (p<0.01). Loss of islet cells results in metabolic deterioration. The lesion precedes development of overt diabetes in Macaea nigra.