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Longitudinal diffusion tensor imaging in a rat brain glioma model

✍ Scribed by Silvia Lope-Piedrafita; Maria L. Garcia-Martin; Jean-Philippe Galons; Robert J. Gillies; Theodore P. Trouard

Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
490 KB
Volume
21
Category
Article
ISSN
0952-3480

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✦ Synopsis

Abstract

In order to investigate the properties of water motion within and around brain tumors as a function of tumor growth, longitudinal diffusion tensor imaging (DTI) was carried out in a rat brain glioma (C6) model. As tumors grew in size, significant anisotropy of water diffusion was seen both within and around the tumor. The tissue water surrounding the tumor exhibited high planar anisotropy, as opposed to the linear anisotropy normally seen in white matter, indicating that cells were experiencing stress in a direction normal to the tumor border. When tumors were sufficiently large, significant anisotropy was also seen within the tumor because of longer‐range organization of cancer cells within the tumor borders. These findings have important implications for diffusion‐weighted MRI experiments examining tumor growth and response to therapy. Copyright Β© 2008 John Wiley & Sons, Ltd.

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