Longitudinal change in forced expiratory volume in healthy, non-smoking men and women: The Baltimore Longitudinal Study of Aging
✍ Scribed by Jay D. Pearson; Stephanie Y. Kao; Larry J. Brant; E. Jeffrey Metter; Melvyn S. Tockman; James L. Fozard
- Publisher
- John Wiley and Sons
- Year
- 1998
- Tongue
- English
- Weight
- 204 KB
- Volume
- 10
- Category
- Article
- ISSN
- 1042-0533
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✦ Synopsis
Studies of age-associated changes in forced expiratory volume at one second (FEV 1 ) have varied in the degree of screening for health and smoking, and have not examined age differences in variability in FEV 1 . Longitudinal rates of change and variability in FEV 1 among healthy lifetimenon-smoking White men and women in the Baltimore Longitudinal Study of Aging (BLSA) are reported. Longitudinal FEV 1 data collected at 2-year intervals for up to 28 yr in 91 men (417 observations) and 14 yr in 82 women (248 observations) were modelled using mixed-effects regression models. Longitudinal percentile distributions of FEV 1 were calculated which reflect age differences in between-subjects variability. The results show that longitudinal rate of decline in FEV 1 is more rapid in men than women (340 ml/decade in men compared to 240-330 ml/decade in women), but similar on a percentage basis (10%) and the difference is not statistically significant; FEV 1 decline begins in early adulthood and progresses at a relatively constant rate over the adult lifespan; longitudinal decline in FEV 1 in BLSA participants is not statistically different from cross-sectional estimates from the BLSA and Crapo et al. (1981); and between-subjects variability is greater in men than women and increases with age. The results document a relatively steady progressive longitudinal decline in FEV 1 in healthy non-smoking White adults, as well as age and gender differences in variability in FEV 1 . The percentile distribution curves reported here are apparently the first reference values for FEV 1 to be derived using longitudinal methods that reflect agespecific differences in variability. Am.