Long term survivors of childhood brain cancer have an increased risk for cardiovascular disease
✍ Scribed by Janneke Heikens; Mathilde C. Ubbink; Heleen P. J. van der Pal; Piet J. M. Bakker; Eric Fliers; Tineke J. Smilde; John J. P. Kastelein; Mieke D. Trip
- Publisher
- John Wiley and Sons
- Year
- 2000
- Tongue
- English
- Weight
- 77 KB
- Volume
- 88
- Category
- Article
- ISSN
- 0008-543X
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✦ Synopsis
BACKGROUND.
Cranial irradiation for children with brain tumors frequently leads to neuroendocrine deficiencies. In this controlled study, the authors investigated risk factors for cardiovascular disease (CVD) for long term survivors of childhood brain cancer. They also tested whether the presence of these risk factors was related to endocrine status.
METHODS.
In 26 survivors of childhood brain cancer (mean age, 25.8 years; mean posttreatment interval, 16 years) and 29 healthy controls (mean age, 27.7 years), the blood pressure, smoking habits, body mass index (BMI), and waist/hip (W/H) ratio were determined. Lipids and lipoproteins were measured and endocrine function was assessed. Carotid intima-media thickness (IMT) measurements were performed by high resolution ultrasonography.