Long-term survivors after adjuvant pelvic irradiation in rectal and sigmoid carcinoma: An assessment of late results
✍ Scribed by Gene Kopelson
- Book ID
- 102925124
- Publisher
- John Wiley and Sons
- Year
- 1983
- Tongue
- English
- Weight
- 708 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0022-4790
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✦ Synopsis
Twenty-six patients with adenocarcinomas of the rectum, rectosigmoid, or sigmoid colon given adjuvant pre-or postoperative pelvic radiation therapy followed at least 5 years were retrospectively reviewed to evaluate late tumor control and complication rates. The overall 7-year survival rate was 80 & 8% with B2,3 patients faring better than C2.3 (94 -t 6% versus 43 & 19%, p < 0.005). Local pelvic tumor control was achieved in 23/ 26 patients (88 %); patients with high-stage (C2J or poorly-differentiated adenocarcinomas had a higher postirradiation pelvic relapse rate (3/ 11) versus low stage, well or moderately-well differentiated tumors (0/ 15). A major complication (none fatal) occurred in 2 of 26 patients (8 %) and was not correlated with either irradiation dose nor volume.
Long-term follow-up is now available on patients who received adjuvant pelvic irradiation for rectal or sigmoid carcinomas and indicates a high pelvic tumor control rate. The 8% major complication rate may be decreased in the future by more sophisticated irradiation treatment planning.